One of the things worth noting is that it would be impossible to get around the area without bridges. On the St. Pete side of Tampa Bay, there are strings of islands that can only be reached by bridges. If you want to travel from St. Pete to Tampa, if you don’t want to spend hours driving around the end of the bay, you’ll need to cross one of Old Tampa Bay’s long bridges. (If you’re flying into Tampa Airport, you’ll see these from the air as you approach.)
Happily, crossing the bridges is quite wonderful. It offers splendid views of the water and whichever city you’re approaching. Depending on the light, it can be absolutely magical.
As with any city, rush hour can be frustrating—but if you’re on vacation, just plan around rush hour. (And if you’re from somewhere like LA, Chicago, or NYC, you probably won’t even recognize Tampa Bay’s rush hour as actually being an issue.)